Abstract
Developmental increase in the muscarinic receptors ([ 3H]quinuclidinyl benzylate binding sites) of rat neonate brain (cerebral cortex and cerebellum) was significantly inhibited by chronic nicotine treatment of the dams during pregnancy and lactation. However, development of the nicotinic receptors ([ 3H]cytisine binding sites) was not inhibited and rather was up-regulated in the cerebral cortex and brainstem by the nicotine treatment. Such inhibition and up-regulation were not seen in nicotine-withdrawn rats after birth. These results suggest that nicotine treatment during lactation may cause a remarkable delay in development of muscarinic neurotransmission in rat neonates.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
