Abstract
COVID-19 is a multisystemic disease with a wild severity range, being some chronic diseases risk factors for unfavorable evolution. It has been suggested are chronic neurological diseases are associated to higher mortality in COVID-19 patients; such association however, has not been described enough. In this context, this study seeks to evaluate whether the presence of previous chronic neurological disease is a factor associated with higher mortality in hospitalized severe cases of COVID-19. For this, the association between those variables was investigated in 87,871 patients through univariate (risk ratio and χ2 test) and multivariate (Poisson regression) analysis. It was found that the mortality rate for patients presenting chronic neurological disease was 23% higher (),this being an independent and statistically significant association (RR = 1.23, 95% CI = 1.2-1.3; p-value < 0.001). Therefore, more studies are needed to better characterize this association.
Highlights
Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a multisystemic disease with a wild severity range, with cases varying from asymptomatic to cases evolving to death
The risk ratio (RR) for the outcome of death between patients with and without chronic neurological disease was 1.23
Poisson Regression aimed to identify the independence of the association between the presence of chronic neurological disease and higher risk of death in relation to age, gender and other chronic diseases
Summary
Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a multisystemic disease with a wild severity range, with cases varying from asymptomatic to cases evolving to death. In this context, it is known that advanced age, obesity, and some chronic diseases (such as hypertension, diabetes, COPD, and cancer) constitute risk factors for unfavorable evolution [1,2,3]. Among the previous chronic conditions for which a relationship with negative outcomes in patients infected with SARS-COV-2 has been suggested are chronic neurological diseases, whose association with this viral infection, has not been described enough [4]. In addition to the indirect health impairment of neurological patients related to health care burden and social constraints [8], it is sought to know if COVID-19 may present with greater severity in these patients
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