Chronic nephropathy induced by prolonged administration of an alcoholic beverage. Recovery experiments.

Abstract

Conclusions1. The chronic renal injury in dogs following the use of the alcoholic distillate when sufficient time is allowed for the development of processes of repair, consists in a type of glomerulonephropathy, characterized by the obliteration of the capillary loop by a large type of connective tissue forming cell. The capsule of the glomerulus does not participate in the reaction. The epithelial cells in the various portions of the tubule appear normal.2. Following the glomerular injury which may have advanced to the stage of hyaline degeneration of the capillary loops, there occurs only slight evidence of an impairment of renal function. Urine from such kidneys constantly contains albumin and occasional hyaline and finely granular casts. The twenty-four hour output of urine when studied on successive days is variable. There is no constant decrease in the output. In four of the animals the output of urine has been markedly in excess of the intake of fluid. Such animals have shown a reduction in body w...