Abstract
Chronic myeloid leukemia is a rare hematological malignancy in the pediatric age group. It is a clonal hematopoietic stem cell disorder in which granulocytes are the major proliferative components with the presence of the BCR-ABL1 fusion gene. Here, we report a case of CML in a three - year child with a clinical presentation of fever and abdominal distension. The diagnosis was made based on bone marrow aspiration findings and molecular study.
Highlights
Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the presence of the breakpoint cluster region (BCR)/ ABL1 fusion transcript encoded by the Philadelphia (Ph) chromosome, a result of a reciprocal translocation between chromosomes 9 and 22.1 The median age at diagnosis of CML is 60 to 65 years and is rare among children and adolescents
The cytogenetic study was carried out, which was positive for 46XX,t(9,22)(q34;q11.2). 98% of the cells were positive for BCR-ABL1 by fluorescence in situ hybridization (FISH) method
The natural history of untreated CML is biphasic or triphasic with most cases diagnosed in the initial CML-chronic phase (CP) followed by an accelerated phase (AP), a blast phase (BP), or both
Summary
Keywords: BCR/ABL1; Chronic myeloid leukemia; Juvenile myelomonocytic leukemia; ABSTRACT Chronic myeloid leukemia is a rare hematological malignancy in the pediatric age group. It is a clonal hematopoietic stem cell disorder in which granulocytes are the major proliferative components with the presence of the BCR-ABL1 fusion gene. Here, we report a case of CML in a three - year child with a clinical presentation of fever and abdominal distension. The diagnosis was made based on bone marrow aspiration findings and molecular study. Citation: Bhatta U, Regmi D. Chronic myeloid leukemia in childhood: A case report. J Pathol Nep 2021;12(2): 1873-5.DOI:10.3126/jpn.v11i2.35291 Copyright: This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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