Abstract
Diagnosis of Chronic myeloid leukemia (CML), a myeloproliferative neoplasia, as well as the assessment of evolutive phase and prognostic score demands: 1) a clinical examination with spleen measurement; 2) blood counts showing hyperleucocytosis with basophilia and immature granulocytic cells at various stages of differentiation; 3) a bone marrow aspirate exhibiting excess of cells belonging to the granulocytic lineage; 4) a karyotype and/or FISH identifying the Philadelphia chromosome, a (9;22) translocation, and/or the fusion gene BCR-ABL1, which codes for the tyrosinekinase protein responsible for the disease; and 5) a polymerase chain reaction (PCR) characterizing the BCR-ABL1 fusion transcript both on qualitative and quantitative basis.
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