Abstract
It has taken time for the status of chronic lymphocytic leukemia (CLL) to change within the scientific community. CLL, characterized by the accumulation of seemingly innocent long-lived monoclonal B cells exhibiting mature morphologies, has long been considered the "Cinderella" of blood cancers. CLL is receiving increasing attention from biologists and clinicians, however, because understanding of this disease may elucidate the association between lymphoid tumous and autoimmunity as well as help to define the relationships between antigen stimulation and malignant transformation.
Highlights
Chronic lymphocytic leukemia (CLL)has been considered the “Cinderella” of blood cancers, receiving less attention than related diseases
CHARACTERISTICS OF CLL CELLS CLL B cells are endowed with a functional B-cell receptor (BCR) that allows Ag interaction [1,2]
Some of these Ag are exposed on the surface of common bacteria. The relevance of these findings is three-fold. They provide the proof of principle that natural Abs in humans present to those in mice, in which natural autoAbs have been described in different settings [17,18,19], such as autoimmunity and removal of senescent cells and bacteria
Summary
Chronic lymphocytic leukemia (CLL)has been considered the “Cinderella” of blood cancers, receiving less attention than related diseases. CLL is a focus of investigation by biologists and clinicians because characteristics of this disease may shed light on the association between lymphoid tumours and autoimmunity as well as help to define the relationships between antigen (Ag) stimulation and malignant transformation.
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