Abstract
Recently, we observed falsely low results by the Abbott IMx Glycated Hemoglobin assay apparently caused by a high number of leukocytes in patients with chronic lymphocytic leukemia. Because chronic lymphocytic leukemia and diabetes mellitus (monitored by glycohemoglobin measurements) occur more frequently in the elderly, we examined this interference further. The IMx Glycated Hemoglobin assay (1) is based on ion-capture technology. A glass-fiber matrix is precoated with a positively charged quaternary ammonium compound that, after hemolysis of the blood sample, electrostatically captures the negatively charged glycohemoglobin complex. A dihydroxyboronate/high-molecular weight polyacrylic acid affinity reagent specifically captures the glycohemoglobin, whereas the nonglycohemoglobin constituents are …
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