Abstract

An unusual case of chronic aleukemic lymphocytic leukemia with dysproteinemia and acquired hemolytic anemia is presented. Significant features included: (1) hyperproteinemia with marked increase of gamma globulins, (2) presence of cold agglutinins of the immune type, (3) decreased red cell survival and (4) abnormal bleeding tendency. Electrophoretic analysis of a lymph node extract revealed a high peak in the area of the gamma globulins corresponding to similar elevations in the serum and in the pleural fluid of the patient. These findings indicate a high concentration of gamma globulin in the leukemic tissue of the patient and suggest that not only normal but also leukemic lymphocytes may be the source of gamma globulins.

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