Abstract
Control of breathing in infants during wake and sleep is immature at birth and undergoes rapid maturation over the first year of life. Infants with chronic lung disease (CLD) have multiple control of breathing impairments leaving them particularly vulnerable to hypoxic and asphyxic events. These impairments in the control of breathing are thought to contribute significantly to increased morbidity and the increased incidence of sudden infant death in infants with CLD. This review provides an overview of factors integral to the control of breathing during wake and sleep and factors that influence the development of control of breathing with a focus on the impact of CLD.
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