Abstract
Liver diseases progresses to more severe forms and thus are a major health problem. Cirrhosis and primitive liver cancer are significantly important in the west and are among the first 10 causes of death in adults. In all chronic liver diseases the final common pathway is liver cirrhosis, characterized by an accumulation of extracellular matrix rich in fibrillar collagens. Cirrhotic patients are at risk of developing many potential complications.One of the major complications of CLDs is Portal hypertension (PH),leads to the progression of portal vein-systemic collateral circulation that includes portal hypertensive gastropathy (PHG) and esophageal and gastric varices. Disabling and distressing manifestation of liver cirrhosis is tense ascites. In the presence of ascites alteration occurs in ventricular function. Cirrhosis may cause renal dysfunction, a common and potentially life threatening complication in hospitalized patients. Both acute kidney injury (AKI) and chronic kidney injury (CKD) are most common, often occurring simultaneously.
Highlights
Chronic liver disease is de ned as an in ammatory injury to the liver, that prolongs for six months or more [1]. it is the combination of many liver abnormalities such as brosis, hepatocyte carcinoma and cirrhosis [2]
The incidence rate is higher in males as compare females [18].Ascites, portal hypertension, hepatorenal syndrome, Hepatic Encephalopathy (HE) andvariceal bleeding are main complications of cirrhosis [19]
Hepatorenal syndrome and hepatic encephalopathy are the complications which occur at the last stage of chronic liver disease
Summary
Chronic liver disease is de ned as an in ammatory injury to the liver, that prolongs for six months or more [1]. it is the combination of many liver abnormalities such as brosis, hepatocyte carcinoma and cirrhosis [2]. Chronic liver disease causes morbidity and mortality worldwide [3]. A days Chronic liver disease is the 5th most common cause of death in United Kingdom. Prevalence rate of chronic liver disease is increasing day by day. Patients with co-morbidities and chronic hepatitis C are at the great risk of developing advanced cirrhosis and Hepatocellular carcinoma [14].
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