CHRONIC KIDNEY DYSFUNCTION BY OCCUPATIONS. RESULTS OF THE ICARIA STUDY: HT.3.02

Abstract

Objective: To investigate the prevalence of chronic kidney dysfunction (CKd), its potential association with cardiovascular risk factors and type of occupations in the Spanish working population. Methods: Cross-sectional study of 194,623 workers (74.2% men, mean age 38.6 years, range 16 to 75) who underwent two routine medical checkups. The estimated glomerular filtration rate (eGFR) was assessed by the Abbreviated Modification of Diet in Renal Disease Study equation. CKd was defined by the mean of two separate eGFR, <73.4 ml/min/1.73m2 in males and <69.7 ml/min/1.73m2 in females. Silent CKd was defined by the presence of CKd with normal serum creatinine level (<1.2 mg/dL in females and <1.3 mg/dL in males). Results: As consequence of definition used, a total of 10.0% (CI 95% 9.9–10.1%) of workers displayed CKd. The prevalence of CKd was equal in both sexes and increased with age. Silent CKd was observed in 8,15% of men and 9.75% of women. White collar occupation was associated with CKd after adjusting for confounders (OR 1.70, 95% CI 1.64–1.76). Overweight, obesity, hypertrigliceridemia, high LDL-cholesterol, and hypertension, were also positively and independently associated with CKd. Table 1 shows the comparison of demographic, anthropometric, and biological variables between workers with chronic kidney dysfunction and workers without it. Table 1. Figures are means or percentages with 95% confidence intervals (within parentheses). Kidney dysfunction was defined by a mean of two separate estimated glomerular filtration rates <73.4 ml/min/1.73m2 in men and <69.7 ml/min/1.73m2 in women. Data available for 194,267 workers. Conclusions: CKd is independently associated with white collar occupation and cardiovascular risk factors in this young and “healthy worker” population, which displays a high prevalence of silent CKd. The eGFR estimation during routine checkups in workers may facilitate early detection of CKd.