CHRONIC KIDNEY DISEASE

Abstract

Objectives: This study aimed to determine the platelet count in diagnosedchronic renal failure patients and to find out the association of platelet count with glomerularfiltration rate. Study Design: Case control study. Place of study: Diagnostic and researchlaboratory Liaquat University Hospital Hyderabad and Nephrology Unit, Isra University HospitalHyderabad. Duration of study: January 2015 to July 2015. Materials and methods: Total ofone hundred and twenty subjects (n=120) were divided into two groups. The healthy controls(n=60) were included in group-I whereas patients with chronic renal failure (n=60) were kept ingroup-II. 5 ml of blood was drawn and sent to laboratory for estimation of serum platelet count,blood urea nitrogen and serum creatinine levels. Results: The present study showed highlysignificant difference with marked decrease in the platelet counts seen in the CRF patientswith 223.9±89.1 million/μL in comparison to the 347.60±55.9 million/μl platelets in controlindividuals. Also the results of BUN in CRF patients showed highly significant differences with27.67±7.68 mg/dl when compared to controls having BUN 8.95±1.02 mg/dl. The comparisonbetween GFR with mean platelet count showed negative correlation (r = -0.27) in CRF patients.Conclusion: The present study shows weak negative correlation of platelet count with GFR.