Abstract
BackgroundPoor physical function is strongly associated with mortality and poor clinical outcomes in adults with chronic kidney disease (CKD). Handgrip strength (HGS) is an important index for physical function in the general population, and the association between HGS and CKD is worth investigating.Methods From September to November 2015, we conducted a cross-sectional study consisting of 10,407 participants in Jurong City, China. Age-related and sex-specific HGS percentile curves were constructed using the GAMLSS method. In addition, logistic regression was applied to estimate the association between HGS and the presence of CKD with odds ratios (ORs) and 95 % confidence intervals (CIs).ResultsParticipants with low HGS tended to be older and were more likely to have CKD (8.73 %). Smoothed centile curves of HGS showed a similar shape in both sexes: participants peaked at approximately 20–35 years old and gradually decreased after the age of 50. In addition, independent of age and other factors, the decreased presence of CKD was significantly identified in individuals with moderate (OR: 0.64, 95 % CI: 0.49–0.83) and high HGS (OR: 0.37, 95 % CI: 0.23–0.58).ConclusionsWe concluded that HGS was significantly negatively associated with CKD in Chinese community-dwelling persons.
Highlights
Poor physical function is strongly associated with mortality and poor clinical outcomes in adults with chronic kidney disease (CKD)
We found that individuals with higher Handgrip strength (HGS) were more likely to be younger and physically active, to be current regular smokers and drinkers and to have higher Body Mass Index (BMI), TG and Estimated Glomerular Filtration Rate (eGFR) values than those with lower HGS
We found that individuals with higher HGS tended to be less likely to have CKD
Summary
Poor physical function is strongly associated with mortality and poor clinical outcomes in adults with chronic kidney disease (CKD). Handgrip strength (HGS) is an important index for physical function in the general population, and the association between HGS and CKD is worth investigating. In 2012, the chronic kidney disease (CKD) prevalence in the general adult population was approximately 10.8 % in mainland China [1]. Patients with CKD typically report lower measures of physical performance than the general population [7,8,9,10]. A sedentary lifestyle commonly commences in the early stages of CKD, which, in turn, leads to a decrease in physical performance, accompanied by a decline in glomerular filtration rate [11, 12]. CKD has systemic effects such as loss of appetite, chronic inflammation, anemia, metabolic acidosis and so on, all of which contribute to a loss of muscle mass and decline in physical performance [8, 11, 12]
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