Abstract
Chronic kidney disease of unknown aetiology in Sri Lanka; a journey to unravel the mystery
Highlights
Chronic kidney disease of unknown aetiology (CKDu) is a major health problem in the North Central Region of Sri Lanka
Ochratoxin A: At the early stages of our research, we considered Ochratoxin A (OA) as a potential cause for CKDu as it was under consideration for Balkan endemic nephropathy at the time
We have a better understanding of the burden, disease profile, geographical distribution and multi-factorial nature of CKDu
Summary
Chronic kidney disease of unknown aetiology (CKDu) is a major health problem in the North Central Region of Sri Lanka. Additional studies are needed to identify whether changing certain practices, such as changing the water source and use of filtered water, could reduce the prevalence of CKDu. To find out the risk factors of the disease, a casecontrol study was carried out in 2007, comparing 183 patients with CRF of unknown aetiology at the renal clinic, Teaching Hospital Anuradhapura with a control group from the general medical clinic of the same hospital.[4] Several risk factors were evaluated.
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