Abstract
Background and AimsChronic kidney disease (CKD) and diabetes mellitus (DM) are considered as risk factors for cardiovascular diseases. The purpose of this study was to clarify the relationship of CKD and DM with the presence of abdominal aortic aneurysm (AAA).MethodsWe enrolled 261 patients with AAA (AAA+) and age-and-sex matched 261 patients without AAA (AAA-) at two hospitals between 2008 and 2014, and examined the association between the risk factors and the presence of AAA. Furthermore, in order to investigate the prevalence of AAA in each group, we enrolled 1126 patients with CKD and 400 patients with DM.ResultsThe presence of CKD in patients with AAA+ was significantly higher than that in patients with AAA- (AAA+; 65%, AAA-; 52%, P = 0.004). The presence of DM in patients with AAA+ was significantly lower than that in patients with AAA- (AAA+; 17%, AAA-; 35%, P < 0.001). A multivariate logistic regression analysis demonstrated that hypertension, ischemic heart disease and CKD were independent determinants, whereas, DM was a negatively independent determinant, for the presence of AAA. The prevalence of AAA in patients with CKD 65 years old and above was 5.1%, whereas, that in patients with DM 65 years old and above was only 0.6%.ConclusionCKD is a positively associated with the presence of AAA. In contrast, DM is a negatively associated with the presence of AAA in Japanese population.
Highlights
Abdominal aortic aneurysm (AAA) is the most popular aortic aneurysm
The presence of diabetes mellitus (DM) in patients with abdominal aortic aneurysm (AAA)+ was significantly lower than that in patients with AAA- (AAA+; 17%, AAA-; 35%, P < 0.001)
A multivariate logistic regression analysis demonstrated that hypertension, ischemic heart disease and Chronic kidney disease (CKD) were independent determinants, whereas, DM was a negatively independent determinant, for the presence of AAA
Summary
Abdominal aortic aneurysm (AAA) is the most popular aortic aneurysm. Previous hospitaland population-based studies reported that the estimated prevalence of AAA in developed countries is 4 to 9% [1,2,3,4,5,6]. Most of AAAs are asymptomatic until rupture. Once rupture occurs, it mostly leads to a rapid clinical course and results in sudden death. The incidence of AAA increases with age, over 60 years old [3, 5, 10]. Since it is expected that the number of elderly population increases in future, the prevalence of AAA could increase substantially. The purpose of this study was to clarify the relationship of CKD and DM with the presence of abdominal aortic aneurysm (AAA)
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