Abstract
One of the most relevant issues of nephrology, neurology, and cardiology is the management and treatment of patients with chronic kidney disease and stroke. Patients with chronic kidney disease have a risk of both thrombotic complications and bleeding, and they have a high risk of both ischemic and hemorrhagic stroke. Chronic kidney disease significantly worsens the outcome of stroke by limiting the treatment due to reduced drug clearance and side effects. Hemodialysis which causes drastic hemodynamic and biochemical changes leads to the "stress" of the cerebral vascular system, increasing the risk of stroke; kidney transplantation reduces the risk of stroke due to functional recovery. Chronic kidney disease and stroke have significant socio-economic consequences. Patients with end-stage chronic kidney disease, as a rule, are not included in clinical trials; and stroke treatment tactics have not been developed for them. This review examines the interaction between kidneys and brain, the pathophysiology and epidemiology of stroke in all stages of chronic kidney disease, after kidney transplantation and discusses the management and treatment of chronic kidney disease patients with stroke.The investigation of the factors responsible for the high prevalence of brain lesions in chronic kidney disease will allow developing new treatment methods.
Highlights
Сочетание хронической болезни почек (ХБП) и повреждений мозга становится все более актуальной темой, заслуживающей большого внимания
Patients with chronic kidney disease have a risk of both thrombotic complications and bleeding, and they have a high risk of both ischemic and hemorrhagic stroke
Chronic kidney disease significantly worsens the outcome of stroke by limiting the treatment due to reduced drug clearance and side effects
Summary
Одной из актуальных тем нефрологии, неврологии и кардиологии является ведение и лечение пациентов с хронической болезнью почек и инсультом. Пациенты c хронической болезнью почек имеют риск как тромботических осложнений, так и кровотечений, у них высок риск как ишемического, так и геморрагического инсульта. Пациентов с терминальной стадией хронической болезни почек, как правило, не включают в клинические исследования, для них не разработана тактика лечения инсульта. В данной работе рассматривается взаимосвязь почек и головного мозга, вопросы патофизиологии и эпидемиология инсульта при всех стадиях хронической болезни почек, после трансплантации почки и обсуждается тактика ведения и лечения пациентов с хронической болезнью почек с инсультом. Ответственных за высокую распространенность поражения головного мозга при хронической болезни почек, позволит разработать новые способы лечения. Ключевые слова: хроническая болезнь почек, инсульт, гемодиализ, трансплантация почки
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