Abstract
The chronic subcutaneous administration of isoproterenol to neonatal and young male and female rats resulted in statistically significant reductions of the norepinephrine concentrations of the heart and submaxillary and parotid glands and increased concentrations in the stellate ganglion. However, the total norepinephrine content of these tissues was not affected. The epinephrine levels of these tissues were not significantly different from controls except for an increased total content in the submaxillary glands. Chronic treatment did not alter the norepinephrine levels of the brain, superior cervical ganglion, adrenal glands, vas de-ferens, uterus, spleen, kidneys, lungs, and small intestine. Growth of neonatal rats was retarded. The wet weights of the submaxillary and parotid glands were significantly greater, while the spleen, uterus, adrenal glands, and stellate ganglion weighed less in iso-proterenol-treated than in control rats. The wet weights of other peripheral tissues were not affected. The ratios of the tissue weight to the body weight were significantly increased for the heart and submaxillary and parotid glands and decreased for the uterus. The first dose of isoproterenol produced hypothermia in mature rats but hyperthermia in newborn rats. Sparse hair growth in neonatal rats and hair loss in weanling rats were also observed during chronic treatment.
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