Abstract
A long term inhalation study was conducted with 500 F344 rats and 60 Cynomolgus monkeys in 5 treatments, in 4 of which they were exposed to aerosolized glass fibres of varying geometry and mass. Exposures of 5 or 15 mg/m3 with long or short lengths, with and without binder were provided for 18 months to monkeys and for 21 months to rats which were subsequently held to 80% mortality. Biological responses evaluated include life table analysis, body weights, clinical signs, haematological testing, respiratory function, ophthalmological examinations, clinical biochemical analysis, and gross and microscopic pathological examinations. Both species demonstrated pulmonary macrophage aggregates and granulomata containing fibrous glass. Rats had grossly visible pleural plaques which were not seen in the monkeys. Fibrogenicity or carcinogenic responses were not seen except for a significantly increased incidence of mononuclear cell leukaemia in each fibre-exposed rat group.
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