CHRONIC HYPERTENSION

Abstract

Background: Hypertension is an important risk factor for cardiovascular morbidity and mortality. Myocardial infarction, andstrokes, which are complications of hypertension, predominantly occur due to thrombosis of arterioles leading to ischemia and infarcts. NOsuppression leads to hypertension associated with haemostatic changes that may endanger life. Material and methods: Rats were randomlydivided into 2 groups equal in number, each contain 20 rats. Group (A) a control group given distillate water and Group (B) hypertension inducedgroup receiving NG-nitro-L-arginine methyl ester (L-NAME) for induction of hypertension. Results: Group 2 showed significant increases of meanblood pressure, plasma fibrinogen levels, significant reduction in mean values of percentages of platelets aggregation, significant increase inmean values of Plasminogen Activator Inhibitor-1 Antigen (PAI-1 antigen), significant increase in mean values of thromin-antithrombin complex(TAT)) and significant increase in mean values of soluble glycoprotein V (sGPV). In contrast, platelets counts showed insignificant changesin its mean values. Conclusion: The present study demonstrates, the increase in plasma fibrinogen levels, fibrinolysis activities as indicatedby increase in plasminogen Activator lnhibitor-1 Antigen (PAI-1 antigen), and systemic plasma thrombin which is detected by increases of meanplasma levels of thromin-antithrombin complex (TAT)) and soluble glycoprotein V (sGPV). Meanwhile decrease in nitric oxide in chronichypertension produces slight decrease in platelets count and aggregation.