Abstract
Latinos with hepatitis C virus (HCV) infection have more rapid progression of fibrosis and decreased response to anti-HCV treatment. The high rates of metabolic syndrome, insulin resistance, and hepatic steatosis, as well as genetic differences, may explain the severity of chronic hepatitis C (CHC) in this population. In addition, Latinos encounter substantial barriers to medical care, including language, cultural differences, and socioeconomic factors such as lack of medical insurance. This article reviews evidence regarding the natural history of CHC in Latinos, efficacy of therapy, and possible strategies to improve outcomes.
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