Abstract
A number of studies have shown that chronic hepatitis B virus infection is implicated in susceptibility to pancreatic cancer. However, the results are still controversial. This meta-analysis aimed to quantitatively assess the relationship between chronic hepatitis B virus infection and incidence of pancreatic cancer of cohort and case-control studies. A literature search was performed for entries from 1990 to 2012 using PUBMED and EMBASE. Studies were included if they reported odds ratios (ORs) and corresponding 95% CIs of pancreatic cancer with respect to the infection of hepatitis B virus. Eight studies met the inclusion criteria, which included five case-control studies and three cohort studies. Compared with individuals who have not infection of hepatitis B virus, the pooled OR of pancreatic cancer was 1.403 (95%CI: 1.139-1.729, P=0.001) for patients with hepatitis B virus infection. Sub-group analysis by study design showed that the summary OR was 1.43 (95%CI: 1.06-1.94, P=0.021) when pooling case-control studies and 1.31 (95%CI: 1.00- 1.72, P=0.05) when pooling cohort studies. Findings from this meta-analysis suggest that chronic hepatitis B virus infection may increase the risk of pancreatic cancer. This relationship needs to be confirmed by further follow-up studies.
Highlights
As one of the most lethal human malignant tumors, pancreatic cancer accounts for 3% of all reported cases of cancer (Jemal et al, 2008)
Inclusion Criteria We screened the relevant studies from the search engines of PUBMED, EMBASE, using the Medical Subject Heading (MeSH) term “hepatitis B virus infection combined with pancreatic cancer or pancreatic neoplasm or pancreatic carcinoma” without language limit
A sensitivity analysis which was performed to evaluate the stability revealed that there was no significant impact on the overall results with removal of any of the studies. In this meta-analysis, we reviewed the case-control studies and cohort studies with the information of chronic hepatitis B infection and pancreatic cancer in four countries or regions
Summary
As one of the most lethal human malignant tumors, pancreatic cancer accounts for 3% of all reported cases of cancer (Jemal et al, 2008). Several studies find that hepatitis B virus can replicate in human pancreatic tissue and that patients with hepatitis B infection have impairments of pancreatic function (Hoefs et al, 1980; Yoshimura et al, 1981; Shimoda et al, 1981; Dejean et al, 1984; Katakura et al, 2005). Some cohort and case-control studies (de Gonzalez et al., 2008; Hassan et al, 2008; Iloeje et al, 2009; Gordon et al, 2009; Hong et al, 2010; Zhu et al, 2011; Wang et al, 2012; Ben et al, 2012) have been conducted to estimate the relationship between chronic hepatitis B virus infection and pancreatic cancer. A meta-analysis was performed to quantitatively assess the relationship of hepatitis B virus infection and the risk of pancreatic cancer in humans
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