Abstract
Chlorophenols (CPs) and related phenoxyacetic acids (PAs) are pesticide groups contaminated with highly toxic 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) during production. PAs and CPs exposure is associated with risk of cancer, but the situation regarding lung cancer has not been clearly defined. We proposed a meta-analysis of published researches to evaluate relationship between chronic exposure to PAs and CPs in pesticide production workplaces and the risk of lung cancer. After searching PubMed, Scopus, Scholar Google, Web of Sciences until August 2013, the association between chronic PAs and CPs exposure in production workplace and lung cancer was studied in 15 cohort studies. The standardized mortality rate (SMR) and 95% confidence intervals (CI) were collected from the papers. We used random or fixed-effects models, Egger test, funnel plot and meta regression in our analysis. Five papers with six reports were included in the final analysis. The standardized mortality rate for lung cancer from the random model was 1.18 (95% CI: 1.03-1.35, p=0.014) with moderate heterogeneity. Publication bias was not found for included studies in meta-analysis (p=0.9). Our findings has strengthen the evidence of lung cancer from chronic exposure to chlorophenol related compounds (PAs, CPs).
Highlights
An increased incidence of lung cancer has been observed in occupational exposure to asbestos (Villeneuve et al, 2012), benzene (Sorahan et al, 2005), cadmium (Adams et al, 2012), beryllium (Kuschner, 1981), hexavalent chromium (Beaver et al, 2009), and nickel compounds (Leem et al, 2010)
We proposed a meta-analysis of published researches to evaluate relationship between chronic exposure to phenoxyacetic acids (PAs) and CPs in pesticide production workplaces and the risk of lung cancer
“chlorophenol”, “phenoxyacetic acid”, “lung cancer” and “dioxin” in PubMed, Scopus, Scholar Google, and Web of Sciences until August 2013 all publications that investigated the association between chronic CPsR exposures in the pesticide production workplace and lung cancer were identified
Summary
An increased incidence of lung cancer has been observed in occupational exposure to asbestos (Villeneuve et al, 2012), benzene (Sorahan et al, 2005), cadmium (Adams et al, 2012), beryllium (Kuschner, 1981), hexavalent chromium (Beaver et al, 2009), and nickel compounds (Leem et al, 2010). CPs and PAs pesticides as Chlorophenols related compounds (CPsR) contaminated to 2, 3, 7, 8 tetrachlorodibenzo-p-dioxin (TCDD) when produce different dioxins during their manufacturing (Lawson et al, 2004). Chlorophenols (CPs) and related phenoxyacetic acids (PAs) are pesticide groups contaminated with highly toxic 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) during production. We proposed a meta-analysis of published researches to evaluate relationship between chronic exposure to PAs and CPs in pesticide production workplaces and the risk of lung cancer. Materials and Methods: After searching PubMed, Scopus, Scholar Google, Web of Sciences until August 2013, the association between chronic PAs and CPs exposure in production workplace and lung cancer was studied in 15 cohort studies. Conclusions: Our findings has strengthen the evidence of lung cancer from chronic exposure to chlorophenol related compounds (PAs, CPs)
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