Abstract
Obesity and aging are associated with hypothalamic inflammation, hyperphagia and abnormalities in the thermogenesis control. It has been demonstrated that the association between aging and obesity induces hypothalamic inflammation and metabolic disorders, at least in part, through the atypical hypothalamic transforming growth factor-β (TGF-β1). Physical exercise has been used to modulate several metabolic parameters. Thus, the aim of this study was to evaluate the impact of chronic exercise on TGF-β1 expression in the hypothalamus of Middle-Aged mice submitted to a one year of high-fat diet (HFD) treatment. We observed that long-term of HFD-feeding induced hypothalamic TGF-β1 accumulation, potentiated the hypothalamic inflammation, body weight gain and defective thermogenesis of Middle-Aged mice when compared to Middle-Aged animals fed on chow diet. As expected, chronic exercise induced negative energy balance, reduced food consumption and increasing the energy expenditure, which promotes body weight loss. Interestingly, exercise training reduced the TGF-β1 expression and IkB-α ser32 phosphorylation in the hypothalamus of Middle-Aged obese mice. Taken together our study demonstrated that chronic exercise suppressed the TGF-β1/IkB-α axis in the hypothalamus and improved the energy homeostasis in an animal model of obesity-associated to aging.
Highlights
The aging is a natural process described such a loss of cellular functions, tissues and organs
The aim of this study was to evaluate the impact of chronic exercise on TGF‐β1 expression in the hypothalamus of Middle‐Aged mice submitted to a one year of high‐fat diet (HFD) treatment
We observed that long‐term of HFD‐feeding induced hypothalamic TGF‐β1 accumulation, potentiated the hypothalamic inflammation, body weight gain and defective thermogenesis of Middle‐Aged mice when compared to Middle‐ Aged animals fed on chow diet
Summary
The aging is a natural process described such a loss of cellular functions, tissues and organs. Aging and obesity are associated with hypothalamic inflammation and loss of anorexigenic and thermogenic signals in the hypothalamus [6, 7]. Hypothalamic inflammation is associated with several age-related diseases such as Alzheimer’s disease, obesity, diabetes type 2, cancer, sarcopenia, with significant risks of morbidity and/or mortality [8]. In this scenario, the transforming growth factor-β (TGF-β), a member of the family of pleiotropic cytokines, has been associated with hypothalamic inflammation and metabolic disorders in obese and aging mice [9]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
