Abstract
The effects of chronic administration of nicotine upon catecholamine (CA) synthesizing enzymes of rat hypothalamus, striatum and adrenal medulla were studied. Nicotine 3 mg/kg/day for 14 days, increased tyrosine hydroxylase (TH) and dopamine-β-hydroxylase (DBH) in hypothalamus and adrenal medulla but did change striatum TH. The data suggest that chronic nicotine administration can produce similar long-term alterations in both of the main CA forming enzymes in hypothalamus and in adrenal medulla.
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