Abstract
The response of parameters of plasma cholesterol metabolism was studied in baboons adapted either to a low-fat, low-cholesterol diet or a high-fat, high-cholesterol diet. Animals adapted to the low-fat diet responded to a single low-fat or high-fat meal, as do normal humans, by a stimulation of cholesterol transport from blood cells to plasma, a stimulation of esterification of cholesterol, and a stimulation of cholesteryl ester transfer to very low and low density lipoproteins. While fasting rates of esterification and transfer increased as a result of diet-induced hypercholesterolemia, the postprandial response was reversed, so that postprandial metabolism was characterized by a movement of cholesterol from plasma to blood cells, an inhibition of cholesterol esterification, and a net transfer of cholesteryl esters from VLDL and LDL to HDL. These data indicate that the effects of postprandial lipemia on plasma cholesterol metabolism critically depend upon fasting plasma cholesterol levels.
Highlights
The response of parameters of plasma cholesterol metabolism was studied in baboons adapted either to a low-fat, low-cholesterol diet or a high-fat, high-cholesterol diet
There is little or no comparable data on the metabolic response to postprandial lipemia in hypercholesterolemia, fasting levels of lecithinxholesterol acyltransferase (LCAT) activity and rates of transfer of preformed cholesteryl esters to very low density lipoproteins (VLDL) and low density lipoproteins (LDL) have been reported to be increased in baboons and rabbits, respectively [6,7]
There was no significant change in plasma cholesterol concentration during postprandial lipemia in any of the studies, a finding consistent with comparable human data [3] and reflecting the relatively high mass of total plasma cholesterol compared to dietary intake
Summary
The response of parameters of plasma cholesterol metabolism was studied in baboons adapted either to a low-fat, low-cholesterol diet or a high-fat, high-cholesterol diet. When the animals were adapted to the high-fat, highcholesterol diet, a major change was evident in the fasting and postprandial balance of cholesterol between blood cells and plasma.
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