Abstract
The objectives of this article are to provide a review for general gastroenterologists of the fluid fluxes in the normal human gut and the pathophysiological mechanisms that lead to chronic diarrhea, and to propose a practical approach to management. Most clinical disorders presenting as chronic diarrhea involve more than one physiological mechanism. The role of motility and functional disorders that result in chronic diarrhea will be emphasized, given the high prevalence of these conditions. There is a growing understanding of the roles of neurotransmitters and hormones in the development of functional gut disorders and intestinal motility and secretion; modulation of these mechanisms also provides a means for novel therapy.
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