Abstract
In 1987, a serological survey among 755 male Norwegian military recruitsshowed that 68 (9.0%) had IgG (7.4%) and / or IgA (4.5%) antibodiesto Y.enterocolitica O:3, consistent with previous infection.In 2004,433 of the former recruits (mean age 37.5 years, range 35 - 42 years) answered a questionnaire, in order to investigatedevelopment of possible chronic disorders and complaints related to uncomplicated Y.enterocolitica infection. The questionnaire covered per-sonal and demographic data, behavioral risk factors, and possible chronic complaints related to yersiniosis.Among the 433 responders, 51 (11.8%) were seropositive for IgG or IgA in the 1987 survey, 380 were seronegative, and 2 had ambiguous results.No difference was observed between the seropositive and seronegativegroups regarding education, annual income, general behavioral risk factors like smoking, alcohol consumption, physical activity, and dietary parameters; or diagnosed chronic illness. However, the seropositives weresignificantly more likely than the seronegatives to report recurrent diarrhea, painful or swollen joints, and muscle pain. Also, presence of all three complaints was more common among seropositives. Conclusion: The present study shows that uncomplicated Y.enterocolitica O:3 infection is a risk factor regarding future development of chronic complaintssuch as diarrhea, and joint and muscle complaint.
Highlights
In 2004, 433 of the former recruits answered a questionnaire, in order to investigate development of possible chronic disorders and complaints related to uncomplicated Y. enterocolitica infection
The present study shows that uncomplicated Y. enterocolitica O:3 infection is a risk factor regarding future development of chronic complaints such as diarrhea, and joint and muscle complaint
Yersinia enterocolitica can cause a range of acute clinical entities including gastro-intestinal disease, hepatitis, pancreatitis, nephritis, arthritis, myalgia, erythema nodosum etc., and multi-organ involvement [1,2,3,4,5]
Summary
Yersinia enterocolitica can cause a range of acute clinical entities including gastro-intestinal disease, hepatitis, pancreatitis, nephritis, arthritis, myalgia, erythema nodosum etc., and multi-organ involvement [1,2,3,4,5]. Clinical and pathological studies indicate that chronic conditions as inflammatory bowel disease, chronic hepatitis, nephritis etc., may be induced [5,8,9,10,11]. Most knowledge about long-term consequences of Y. enterocolitica infection has been obtained from retrospective or follow-up studies of hospitalized patients [5, 11,12,13,14], from case-control studies of culture-confirmed cases [15], and from immuno-histochemical examination of specimens from patients with supposed chronic manifestations of Y. enterocolitica infection [16,17,18]. Studies based on patients with diagnosed Y. enterocolitica infection, whether hospitalized or not, are likely to be biased both in terms of the nature and severity of clinical manifestations. More representative data may be obtained from patients identified by screening of the population as whole, or of population subsets
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