Chronic co-treatment of NS398 (COX-2 inhibitor) with MTEP changes strategy of mice in Barnes Maze, through membrane resistance variation

Abstract

The aim of this study was to explore potential relationships between serum BDNF levels and depression in systemic lupus erythematosus (SLE) patients.We included 208 consecutive SLE patients and 100 age-and sex-matched healthy controls. The presence of depressive symptoms was determined through the Beck Depression Inventory-II (BDI-II) score.The serum BDNF levels were significantly (P < 0.0001) higher in SLE patients as compared to normal controls. There was a negative correlation between levels of BDNF and the SLE disease activity index 2000 (SLEDAI–2K) (r = −0.349, P < 0.0001). Depression (defined as BDI-II score ≥ 18) was identified in 54 SLE patients (26.0%, 95%CI: 20%–31.9%). The serum BDNF levels were significantly lower in depression patients at the time of admission as compared with patients without depression [27.6(IQR, 23.2–30.4)ng/ml vs. 36.2(IQR, 31.7–42.3)ng/ml; P < 0.0001]. Compared with the first quartile of serum BDNF levels, the second quartile OR for depression was 0.72 (95% CI, 0.61–0.80, P = 0.033). For the third and fourth quartiles, it was 0.42 (95% CI, 0.33–0.52, P = 0.002) and 0.16 (95% CI, 0.09–0.24; P < 0.001).Serum BDNF levels are decreased in SLE patients with depressive symptoms. In SLE, serum BNDF levels are independently associated with depressive disorders, suggesting the role of neurotrophic factors in depression.