Abstract
A chronic brain blood-flow imaging device was developed for cerebrovascular disease treatment. This device comprises a small complementary metal-oxide semiconductor image sensor and a chronic fiber-optic plate window on a mouse head. A long-term cerebral blood-flow imaging technique was established in a freely moving mouse. Brain surface images were visible for one month using the chronic FOP window. This device obtained brain surface images and blood-flow velocity. The blood-flow changes were measured in behavioral experiments using this device. The chronic brain blood-flow imaging device may contribute to determining the cause of cerebrovascular disease and the development of cerebrovascular disease treatment.
Highlights
In drug discovery and disease research, small experimental animals are used for the evaluation of treatments
An implantable complementary metal-oxide semiconductor (CMOS) device was developed for blood-flow imaging, and an implantable micro imaging device was developed for deep-brain imaging [7,8,9]
Measuring long-term cerebral blood flow was difficult using the implantable CMOS device was developed in our previous study [10,11], because animal movement and tissue inflammation led to bleeding on the brain surface
Summary
In drug discovery and disease research, small experimental animals are used for the evaluation of treatments. A chronic window technique on the small animal brain was developed to solve this issue [1,2] and to enable repeated brain imaging with a living mouse This technique implants a thin glass on the brain surface, allowing observation with an imaging microscope through the glass. An implantable complementary metal-oxide semiconductor (CMOS) device was developed for blood-flow imaging, and an implantable micro imaging device was developed for deep-brain imaging [7,8,9] In long-term experiments, the implanted device moved in the brain, and the imaging area was obstructed. A blood-flow imaging device was developed for long-term and repeated behavioral experiments with the same small experimental animal. The result of this study could contribute to the understanding of bloodflow systems in the brain related to drug potency for diseases
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