Chronic biological effects of methyl methacrylate vapor: III. Histopathology, blood chemistries, and hepatic and ciliary function in the rat

Abstract

Inhalation experiments were conducted by exposing rats, mice, and frogs to methyl methacrylate (MMA) monomer vapor in air. Rats were exposed for periods of up to 6 months to near threshold limit value (TLV) concentrations and for a shorter period to approximately ten times the TLV. Blood chemistries were unremarkable. Histopathological findings were essentially nil except for microscopic indications of damage to the tracheal mucosa, supported by scanning electron microscopy (SEM) observations that the cilia and microvilli characteristic of these epithelial cells were absent. A reduction in oropharyngeal transport efficiency was shown when frogs were exposed to 400 ppm of MMA vapor. The sodium pentobarbital detoxification function of mouse liver may be altered consequent to exposures to 160 hr to both 100 and 400 ppm of MMA vapor. It is concluded that, at the TLV, cellular responses may be manifested regardless of whether gross systemic effects are seen.