Chronic aortic denervation plus high sodium diet. A model of salt‐sensitive normotension in rat

Abstract

To assess whether progressive arterial baroreceptor denervation results in salt‐sensitive changes in blood pressure, mean arterial pressure (MAP) was measured in six groups of conscious male Wistar rats before and ∼30 days after bilateral: a) sham denervation (SH), b) sino‐aortic denervation (SD) and c) aortic denervation (AD). During the last 21 days of post‐denervation period three groups received high sodium diet (HNa = 8%) and the other three groups low sodium diet (LNa = 0.04%). The remaining baroreflex control of ERSNA was examined in the anesthetized state as %Δ ERSNA vs MAP. The modelling indicated that there were no effects of denervation nor diet on MAP ∼ 30 days after denervation. However, the modelling of Δ MAP (MAP after – MAP before) indicated effect of both denervation and diet but not interaction, the highest and more lasting Δ MAP being observed in AD + HNa group (21± 3 mmHg). The modelling of remaining baroreflex control of ERSNA indicated effect of denervation but not of diet.Conclusion:AD + HNa is a novel experimental model of salt‐sensitive normotension, though AD does not impair the remaining baroreflex control of ERSNA.Supported by: SMRF06‐UASLP Range % Slope %/mmHg X to ½ range mmHg Lower Plateau % Gmax SH 119± 7 −.085±.007 130±5 −85±6 −2.5±0.1 AD 125± 9 −.065±.005* 128±4 −82±5 −2.0±0.2 SD 61± 6* −.059±.005* 153±7* −66±6* −.9±.1* p<0.05 vs SH. Conclusion:AD + HNa is a novel experimental model of salt‐sensitive normotension, though AD does not impair the remaining baroreflex control of ERSNA.Supported by: SMRF06‐UASLP