Abstract
BackgroundRisk factors for the development of chronic antibiotic dependent pouchitis (CADP) are not well understood.MethodsUsing multivariable logistic regression, we compared clinical factors between 194 patients with acute antibiotic responsive pouchitis or CADP.ResultsIndividuals with CADP were significantly older (40.9 vs 30.8 years, P < 0.001) and demonstrated a longer disease duration before IPAA (10.3 vs 7.0 years, P = 0.004). Age ≥55 years at the time of IPAA was significantly associated with CADP (adjusted odds ratio = 4.35, 95% confidence interval = 1.01–18.7).ConclusionsAlthough older age should not represent a barrier to IPAA, further studies evaluating etiologies of this association are warranted.
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