Abstract
Cough is a frequent symptom reported in general practice consults. Even though most of the cases concern acute and self limiting episodes, if cough persists a comprehensive diagnostic evaluation should be started. Patients that scarcely respond to empiric therapy or whose symptoms are not clearly referable to one of the most common causes of cough may receive the diagnosis of unexplained cough. These patients frequently develop depression or social retirement. Recent studies have suggested that hypersensitivity of the cough reflex could be the pathogenic mechanism underlying unexplained cough. However hypersensitivity syndrome should not be used as an easy way out for patients with a complicated history of cough. Through our paper we will briefly review the most common causes of cough and how they could be involved in the development of hypersensitivity cough syndrome.
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