Abstract
Serotonin (5-HT) is a vasoactive autocoid, but its role in systemic blood pressure regulation is unclear. The role of 5-HT in hypertension is not understood though arteries from different models of hypertension are hypercontractile to 5-HT. We hypothesized that chronic 5-HT infusion would lead to increased blood pressure and arterial 5-HT content in normotensive rats; these responses would be enhanced in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. 5-HT (25 ug/kg/min) or vehicle was administered via osmotic pump for 1 week to normotensive and established hypertensive rats. Within 24 hours post-pump implantation, radiotelemeter measurement of mean arterial pressure in the normotensive 5-HT infused group fell 23 mmHg (table). This hypotensive response was enhanced in the DOCA 5-HT infused group in which mean arterial pressure fell 63 mmHg. These findings are the first to demonstrate the long-term effects of 5-HT on blood pressure, and indicate the net effect of chronic increases in circulating 5-HT is decreased blood pressure. This is counterintuitive given arterial hyperresponsiveness to 5-HT in vivo and in vitro, suggesting the effects of 5-HT in the cardiovascular system are considerably more complex than currently appreciated. Mean Arterial Pressure (mmHg)
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