Abstract
Data obtained from analysing chromosomal organization and interactions in individual cells unify previous results obtained by single-cell imaging and studies of population-averaged genomic interactions. See Article p.59 The latest genomic techniques such as Hi-C, based on chromosome conformation capture (3C), can detect chromatin interactions and provide a three-dimensional picture of chromosome organization in the nucleus. The resulting data, averaged over millions of gene loci, are not directly relevant to the organization of a single cell. Peter Fraser and colleagues have bridged the gap between genomics and microscopy studies by developing a single-cell Hi-C approach that allows the detection of thousands of simultaneous genomic contacts in an individual cell. Using the system together with a three-dimensional structural model of the X chromosome, the authors demonstrate how chromosome territory structures vary from cell to cell, particularly the interdomain and trans-chromosomal contacts.
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