Chromosomenbestand und-morphologie der Zellen des Ehrlich-und des MCa1-Ascitestumors der Maus

Abstract

Our investigations on the karyological behaviour of our Ehrlich ascites tumour and the ascites type of the MCal tumour showed characteristic differences. 92 per cent of the cells from the Ehrlich ascites tumour were almost diploid (36–46 chromosomes) and 8 per cent were about tetraploid (78–87 chromosomes). A complex of 42 chromosomes was present in the main number of the diploid tumour cells. On the other hand the cells in the MCal ascites tumour contained chiefly hypodiploid sets of chromosomes with a maximum of 36, and a variation from 34–44 chromosomes. Tetraploid complexes of chromosomes were found in 12 per cent of the MCal tumour cells. The chromosome number ranged here from 70–80 with a maximum of 72. In the two ascites tumours we saw atypically formed chromosomes of 3 different types: 1. chromosomes with an achromatic gap near the middle of the chromosome body (type A), 2. straight chromosomes with a median centromer (type B), and 3. V-shaped chromosomes with a median centromer. In the MCal ascites tumour the number of these atypical chromosomes was considerably greater than in the Ehrlich ascites tumour.