Abstract
Article1 December 1963Chromosome Patterns in Irradiated and Nonirradiated Patients with Rheumatoid SpondylitisDAVID S. NEWCOMBE, M.D., ALAN S. COHEN, M.D.DAVID S. NEWCOMBE, M.D.Search for more papers by this author, ALAN S. COHEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-6-859 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the introduction of relatively simple and specific methods for the analysis of human chromosomes, studies of heritable or genetically determined disorders have been extensive. Rheumatoid spondylitis would appear to be an appropriate disorder for such chromosome analyses for several reasons. First, there are indications that genetic mechanisms may play a role in its etiology, that is, the strong tendency toward the familial occurrence of spondylitis, the apparently autosomal dominant type of inheritance with incomplete penetrance, and the appearance of the disorder in twins (1). Second, X-irradiation, now associated with a documented increased incidence of leukemia (2), has been used...
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