Abstract
Chromosome instability syndromes are defined by either an increase of chromosomal breakage or by an increases of sister chromatid exchange number, or by an increase of the 2. Bloom's syndrome, ataxia telangiectasia, fanconi's anemia and xeroderma pigmentosum are the main components of this group. The incidence of cancers or malignant blood diseases in the involved individuals is high. The finding of DNA repair abnormalities in some of the and their high sensitivity to particular mutagenic agents makes those syndromes an interesting model for oncogenesis.
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