Chromosome errors involving large metacentric and submetacentric chromosomes are more common in young infertility patients

Abstract

Advanced maternal age (AMA) is the most significant risk factor associated with oocyte aneuploidy. Women at 40 years of age have a 50% reduction in fecundity compared to women a decade younger, including a significant increase in pregnancy loss. Chromosome analysis of pre-implantation embryos has revealed that all 23 pairs of chromosomes are involved in both chromosome gains and losses. The aim of this study was to evaluate the classification of blastocyst chromosome errors in association with maternal age at the time of infertility treatment.