Abstract

A NUMBER of tumours of mice, rats, Chinese hamsters and man consist of a cell population with aneuploid chromosome numbers1–4. These observations are frequently quoted in support of the theory that somatic chromosomal mutations are involved in the process of carcinogenesis. The greater part of the published results concerns tumours in the ascites form, or long-established transplanted tumours, and it is not clear whether these results also apply to primary tumours. The few results obtained so far on primary carcinoma of man show the occurrence of aneuploid cells5,6, whereas the mammary tumour of C3H mice consists of a cell population with a diploid chromosome number7: the question can be raised as to whether the differences in chromosomal behaviour are due to different methods of tumour induction. In regard to this problem virus-induced tumours appeared of particular interest.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.