Abstract
Human short term leukocyte cultures have been exposed to Co60 and H3-uridine irradiation. At the time of their first mitotic event the cells are collected. In the cultures treated with H3-uridine mainly breaks of chromatid type are found, whereas the Co60 irradiated cells have only breaks of chromosome type as long as the irradiation takes place before the onset of DNA synthesis. It is inferred that H3-uridine causes damage to localized single stranded DNA loops separated during transcription in RNA synthesis and inaccessible to repairing. The results are interpreted as an indication that the chromosome (chromatid) continuity is dependent on one DNA double helix strand and that the subunits of the chromosome, as revealed by radiation, is in fact single-stranded DNA.
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