Abstract
A survey of the chromosome constitution of unselected necropsied infants dying in hospital in the perinatal period was carried out in South and East London over a period of two years and nine months. Chromosome results were obtained from 500 of the 726 infants examined. There were 28 infants with chromosome abnormalities, accounting for 9% of macerated stillbirths, 4% of fresh stillbirths, and 6% of early neonatal deaths for which results were obtained. Chromosome abnormalities were found in 13% of infants with lethal malformations and 2.5% of infants dying from other causes. The incidence of E18-trisomy in this survey indicates that this abnormality is more common at birth than is generally accepted. It is suggested that a chromosome analysis should be an integral part of the perinatal necropsy.
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