Abstract
BackgroundNeuroblastoma (NB) is the most common extracranial solid tumor in children. It is known for high heterogeneity and concealed onset. In recent years, the mechanism of its occurrence and development has been gradually revealed. The purpose of this study is to summarize the clinical characteristics of children with NB and abnormal chromosome 10, and to investigate the relationship between the number and structure of chromosome 10 abnormalities and NB prognosis.MethodsChromosome G-banding was used at the time of diagnosis to evaluate the genetics of chromosomes in patients with NB and track their clinical characteristics and prognosis. All participants were diagnosed with NB in the Medical Oncology Department of the Beijing Children’s Hospital from May 2015 to December 2018 and were followed up with for at least 1 year.ResultsOf all 150 patients with bone marrow metastases, 42 were clearly diagnosed with chromosomal abnormalities. Thirteen patients showed abnormalities in chromosome 10, and chromosome 10 was the most commonly missing chromosome. These 13 patients had higher LDH and lower OS and EFS than children with chromosomal abnormalities who did not have an abnormality in chromosome 10. Eight patients had both MYCN amplification and 1p36 deletion. Two patients had optic nerve damage and no vision, and one patient had left supraorbital metastases 5 months after treatment.ConclusionsThe results indicated that chromosome 10 might be a new prognostic marker for NB. MYCN amplification and 1p36 deletion may be related to chromosome 10 abnormalities in NB. Additionally, NB patients with abnormal chromosome 10 were prone to orbital metastases.
Highlights
Neuroblastoma (NB) is the most common extracranial solid tumor in children
The survival curves for only in survival (OS) or Event-free survival (EFS) were generated via the Kaplan-Meier method, and the difference between the two groups was evaluated with a log-rank test
Parodi et al came to a preliminary conclusion that the prognosis of children with NB and whole Xchromosome-loss is relatively poor, which can be used as a new prognostic indicator, and patients with this chromosomal abnormality should be treated in the IR group [18]
Summary
Neuroblastoma (NB) is the most common extracranial solid tumor in children. It is known for high heterogeneity and concealed onset. Neuroblastoma (NB) is a malignant solid tumor of children originating in the adrenal medulla and sympathetic nervous system [1] It is the widely diagnosed in children, with 8–10.2 cases of NB occurring per million. Children with high-risk NB at Stage IV, without MYCN gene amplification, and with a whole chromosome aneuploidies (WCAS) factor of less than 2 have a poorer prognosis than those with a WCAS factor of greater than 2. This phenomenon is most significant on chromosome 10 (P = 0.002) [7]. Abnormalities in number occurred frequently on chromosomes 21, 10, and 11, with abnormalities on chromosome 10 being the most frequent
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