Abstract
The gene for insulin-like growth factor II (IGF-II) receptor (IGF2R) that has recently been found, by DNA sequencing, to be identical to the cation-independent mannose 6-phosphate receptor (CIM6PR) has been mapped in the human and murine species. Cloned cDNAs for human and rat IGF-II receptors were used to probe Southern blots of somatic cell hybrid DNA and for in situ chromosomal hybridization. The genes are located in a region of other conserved syntenic genes on the long arm of human chromosome 6, region 6q25 → q27, and mouse chromosome 17, region A-C. The CIM6PR IGF2R locus in man is asyntenic with the genes encoding IGF-II ( IGF2), the IGF-I receptor ( IGF1R), and the cation-dependent mannose 6-phosphate receptor ( CDM6PR).
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