Abstract
This chapter discusses the chromosomal location of immunoglobulin genes. The chromosomal localization of Ig genes in man and mouse is firmly established. The results with mouse–rabbit hybridomas indicates that it is possible to localize Ig genes in rabbit chromosomes, although these hybridomas are unstable and do not allow correlations to be made between enzyme gel electrophoresis of biochemical markers and chromosomal segregation. Rabbit chromosomes are especially suitable for comparison with human chromosomes. Banding similarities for Ig heavy chain genes carrying chromosomes in the three species examined in the chapter extend to most of the chromosome. In addition, Genes for Ig heavy chains can be definitively assigned to the homoeologous region of human chromosome 14, mouse chromosome 12, and rabbit chromosome 16. The mapping of IGH genes in these three species is in agreement with chromosome banding similarities and the genes can confidently be assigned to a specific band located at the distal part of these chromosomes.
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