Abstract
Human class I alcohol dehydrogenase (alcohol:NAD + oxidoreductase, EC 1.1.1.1; ADH) is the major enzyme involved in ethanol oxidation. Three highly homologous genes govern the synthesis of three types of subunits which form several ADH isozymes. The locus for class I ADH loci was previously assigned to q21–25 of chromosome 4 by somatic cell hybridization techniques. Analysis of grain positions by in situ hybridization of chromosomes indicated that the ADH cluster locus is on 4q21–23, probably 4q22.
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