Abstract
The CCT (chaperonin containing TCP-1) complex functions as a molecular chaperone in the eukaryotic cytosol. This complex consists of several species of related polypeptides. The chromosomal localization of the mouseCct4gene encoding the delta subunit of CCT was assigned in this study to proximal chromosome 11 by genetic mapping. Restriction mapping analysis using YAC and pulse-field gel electrophoresis showed thatCct4is located within a region about 300 kb from the imprinted geneU2af1-rs1. Expression ofCct4was biallelic, and thereforeCct4is not imprinted in neonatal mice. The localization of the human homologue ofCct4on chromosome 2 corresponds well with the fact that homologues of other genes in the proximal region of mouse chromosome 11 also map to the region of conserved synteny in human chromosome 2.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
