Abstract
Direct testing of the outcome of human female meiosis demonstrated that up over a half of oocytes from IVF patients of advanced reproductive age are aneuploid, originating comparably from meiosis I and meiosis II errors, with potential probability of aneuploidy rescue in an almost half of oocytes with sequential first and second meiotic errors. One fifth of abnormalities originating from meiosis I and II are of complex nature, with nonrandom distribution of chrmomatid/chromosome (10:1 ratio), and missing/extra chromotid (chromosome) errors (2:1 ratio). The data also demonstrate the relationship between embryo viability and meiotic origin of chromosomal errors, affecting their clinical impact on preimplantation and post-implantation development
Highlights
According to DNA polymorphism studies performed in families with aneuploid spontaneous abortions and live-born babies, chromosomal abnormalities originate predominantly from female meiosis I, probably due to reduction of meiotic recombination rate with advanced reproductive age [1,2,3]
It was suggested that meiosis II errors may, on the opposite, be a result of the increased meiotic recombination rate [4]
This was based not on the direct testing of meiosis errors, but limited to the testing of those products of conception that are compatible with implantation, resulting in recognized pregnancies, which either survived to term or aborted spontaneously
Summary
According to DNA polymorphism studies performed in families with aneuploid spontaneous abortions and live-born babies, chromosomal abnormalities originate predominantly from female meiosis I, probably due to reduction of meiotic recombination rate with advanced reproductive age [1,2,3]. Prevalence of Aneuploidies in Preimplantation Development Based on Direct Testing of Female Meiosis Outcome
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