Abstract
Chromosomal aberrations induced by simultaneous treatment with mercury compound and selenium compound in human lymphocyte cultures were studied. When cultures were treated with methylmercuric chloride (MMC) or mercuric chloride alone, MMC showed higher activity for chromosome damage than mercuric chloride. Regarding effects of selenium compounds on the chromosomal aberrations induced by mercury compounds, selenious acid showed a marked protection effect against chromosome breakage by MMC or mercuric chloride. However, sodium selenate enhanced the chromosome-breaking activity of MMC and mercuric chloride. On the other hand, MMC or mercuric chloride showed a protective effect against chromosome breakage by selenious acid. Mercuric chloride was more protective than MMC to human lymphocytes.
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