Abstract
BackgroundChromophobe renal cell carcinoma is the third most common form of adult renal epithelial neoplasm. A sarcomatoid component occurs in approximately 8% of all chromophobe renal cell carcinoma cases, while metaplastic bone formation is extremely rare.Case presentationAn abdominal computed tomography scan revealed a hypovascular tumor with focal calcification, measuring 2.5 × 2.3 cm, in the upper pole of the right kidney. The tumor was clinically diagnosed as a right renal cell carcinoma that showed signs of calcification, and a laparoscopic right radical nephrectomy was performed. The cut surface of the tumor was beige in color and indicated that the tumor was an extensively ossified mass. Histological analysis revealed three distinct morphological components of the tumor. The chromophobe renal cell carcinoma consisted of compact epithelial cells arranged in a nested pattern, and these were mixed with extensive areas of sarcomatoid spindle cells with marked nuclear pleomorphism and brisk mitotic activity. The tumor also contained multiple foci of metaplastic ossification.ConclusionChromophobe renal cell carcinoma with concomitant osseous metaplasia and sarcomatoid transformation is a very rare occurrence.
Highlights
Chromophobe renal cell carcinoma is the third most common form of adult renal epithelial neoplasm
The 5- and 10-year cancer-specific survival rates have been reported to be 100% and 90%, respectively [1], sarcomatoid differentiation of Chromophobe renal cell carcinoma (CRCC) is generally associated with a worse prognosis [2,3]
A sarcomatoid component occurs in approximately 8% of all CRCC cases [2], while metaplastic bone formation is extremely rare [4]
Summary
Chromophobe renal cell carcinoma (CRCC) is the third most common form of adult renal epithelial neoplasm, accounting for 5.9% of all RCC cases [1], and has a better prognosis than clear cell carcinoma. The 5- and 10-year cancer-specific survival rates have been reported to be 100% and 90%, respectively [1], sarcomatoid differentiation of CRCC is generally associated with a worse prognosis [2,3]. Malignant tumors with sarcomatoid change had a 35% and 27%, 5-year diseasespecific and progression-free survival, respectively [1]. Admixed with the CRCC were extensive areas of sarcomatoid spindle cells with marked nuclear pleomorphism and brisk mitotic activity (Figure 5). The spindle cells were arranged in ill-defined fascicles with a focal storiform pattern, exhibiting an aggressive growth pattern with extracapsular invasion into the adipose tissue. Another feature of this tumor was the presence of multiple foci of metaplastic. The patient is alive and free from disease 12 months after surgery
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
